Background: One of the greatest challenges of the XXI. century is the changing of the medical profession. Beside of the process of deprofessionalism, the demographic and social composition of the medical society have also been altering. More women became medical doctors in recent years. Parallel to these changes, the career motivations of medical students are transforming. Method: 175 first year medical students from the Semmelweis University participated in our study. They wrote about their career motivations based on a fixed set of viewpoints. The narratives were analysed by both quantitative and qualitative (content analysis) methods. Results: The female students are committed to medical profession at younger ages. The most important factors in career choices are altruism and scientific interest for both genders. There is a male dominance in career motivations of experiences, knowledge and benefits. Conclusions: The changing face of career motivations has a significant impact on both the physicians and the patients. This issue opens up possibilities for following research.