In this paper we provide data on the flora of Monostorpályi, a floristically underrepresented settlement in South-Nyírség and Berettyó–Kálló interfluve, and publish some interesting floristic observations from the Debrecen city area. In our compilation we provide data on 58 plant species. Among the species listed in the enumeration we find taxa from the region not previously reported at all (Lathyrus nissolia, Gagea villosa, Catabrosa aquatica, Potamogeton lucens, P. pusillus). In total, we publish new occurrence data for 16 protected plant species, which are generally typical of the natural habitats of the Nyírség, but are on the decline overall (e.g. Hottonia palustris, Dianthus superbus, Cirsium rivulare, Lychnis coronaria). We also provide data on the distribution of some rare or declining weed species (Anthemis cotula, Myagrum perfoliatum, Agrostemma githago) and confirm the previously known occurrence of some poorly known plant species (Luzula pallidula, Carex hordeistichos). Furthermore, the spread of some alien species (Broussonetia papyrifera, Phyllostachys sp.) is also highlighted.