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Understanding leptin’s influence on calf development: A review of metabolic and reproductive mechanisms

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2025-06-08
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Tóth, E., Rátky, J., Posta, J., & Knop, R. (2025). Understanding leptin’s influence on calf development: A review of metabolic and reproductive mechanisms. Acta Agraria Debreceniensis, 1, 145-153. https://doi.org/10.34101/actaagrar/1/15629
Received 2025-04-14
Accepted 2025-05-08
Published 2025-06-08
Abstract

Leptin, a hormone primarily produced by adipose tissue, regulates the energy balance, metabolism, and reproductive functions. This review explores leptin's role in calf development from embryogenesis to puberty. Leptin expression is strongly influenced by the nutritional status, with circulating levels dependent on adipose tissue mass and modulated by metabolic hormones such as insulin and glucocorticoids. It plays a regulatory role in the embryonic cell division, adipogenesis, and postnatal energy metabolism. Additionally, leptin modulates appetite, the growth hormone secretion, and the reproductive system maturation. Its presence in the colostrum and milk highlights its significance in the early calf development, influencing the neonatal metabolism and immune function. As calves approach puberty, leptin serves as a key metabolic signal for reproductive maturation. A deeper understanding of leptin’s multifunctional role in calf development could contribute to improved livestock growth and reproductive management strategies.

References
  1. Amstalden, M.; Garcia, M.R.; Williams, S.W.; Stanko, R.L.; Nizielski, S.E.; Morrison, C.D.; Keisler, D.H.; Williams, G.L. (2000): Leptin gene expression, circulating leptin, and luteinizing hormone pulsatility are acutely responsive to short-term fasting in prepubertal heifers: relationships to circulating insulin and insulin-like growth factor I (1). Biol. Reprod.; 63:127–133. https://doi.org/10.1095/biolreprod63.1.127
  2. Amstalden, M.; Alves, B.R.; Liu, S.; Cardoso, R.C.; Williams, G.L. (2011): Neuroendocrine pathways mediating nutritional acceleration of puberty: insights from ruminant models. Front Endocrinol. 2:3389. doi: 10.3389/fendo.2011.00109
  3. Amstalden, M.; Cardoso, R.; Alves, B.; Williams, G.L. (2014): Reproduction Symposium: Hypothalamic Neuropeptides and The Nutritional Programming of Puberty in Heifers. J. Anim. Sci. 92:3211–3222. DOI: 10.2527/jas.2014-7808
  4. Arieli, A.; Schrama, J.W.; Van Der Hel, W.; Verstegen, M.W. (1995): Development of Metabolic Partitioning of Energy In Young Calves. Journal of Dairy Science, 78, 5, 1154–62. Doi:10.3168/Jds.S0022-0302(95)76732-7
  5. Apter, D. (2003): The Role Of Leptin In Female Adolescence Volume 997, Issue 1 Women's Health And Disease: Gynecologic And Reproductive Issue Pages: IX–XII, 1–388. doi: 10.1196/annals.1290.008
  6. Block, J.; Drost M.; Monson, R.L.; Rutledge, J.J.; Rivera, R.M.; Paula-Lopes, F.F.; Ocon, O.M.; Krininger, C.E.; Liu, J.; Hansen, P.J. (2003): Use of Insulin-Like Growth Factor-I During Embryo Culture and Treatment of Recipients with Gonadotropin-Releasing Hormone to Increase Pregnancy Rates Following the Transfer of in Vitro-Produced Embryos to Heat-Stressed, Lactating Cows. J. Anim. Sci., 81, 1590–1602. DOI: 10.2527/2003.8161590x
  7. Block, S.S.; Smith, J.M., Ehrhardt, R., Diaz, M., Rhoads, R.P., Amburgh, M.E., Boisclair, Y.R. (2003): Nutritional and Developmental Regulation of Plasma Leptin in Dairy Cattle. Journal of Dairy Science, 86, 10, 3206–14. Doi:10.3168/Jds.S0022-0302(03)73923-X
  8. Blum, J.W.; Zbinden, Y.; Hammon, H.M.; Chilliard Y. (2005): Plasma Leptin Status in Young Calves: Effects Of Pre-Term Birth, Age, Glucocorticoid Status, Suckling, And Feeding With An Automatic Feeder Or By Bucket. Domestic Animal Endocrinology, 28, Issue 2, February, 119–133. DOI: 10.1016/j.domaniend.2004.06.011
  9. Brown, W.E.; Holdorf, H.T.; Kendall, S.J.; White, H.M. (2023): Dam Body Condition Score Alters Offspring Circulating Cortisol and Energy Metabolites In Holstein Calves But Did Not Affect Neonatal Leptin Surge. Metabolites , 13, 631. https://Doi.Org/10.3390/Metabo13050631
  10. Cammell, S.B.; Haines, M.J.; Gill, M.; Dhanoa, M.S.; France, J.; Beever, D.E. (1993): Examination of Energy Utilization in Cattle Offered a Forage Diet at Near- And Sub-Maintenance Levels of Feeding. British Journal of Nutrition, 70, 381–392. Doi:10.1079/Bjn19930133
  11. Campfield, L.A.; Smith, F.J.; Guisez, Y.; Devos, R.; Burn, P. (1995): Recombinant Mouse Ob Protein: Evidence for A Peripheral Signal Linking Adiposity and Central Neural Networks. Science, 269, 546–549. DOI: 10.1126/science.7624778
  12. Cannon, B.; Nedergaard, J. (2004): Brown Adipose Tissue: Function and Physiological Significance. Physiol. Rev., 84, 277–359. DOI: 10.1152/physrev.00015.2003
  13. Cardoso, R.C.; Alves, B.R.; Williams, G.L. (2018): Neuroendocrine Signaling Pathways and The Nutritional Control of Puberty in Heifers. Anim Reprod; 15:868–878. doi: 10.21451/1984-3143-AR2018-0013
  14. Caro, J.F.; Sinha, M.K.; Kolaczynski, J.W.; Zhang, P.L.; Considine, R.V. (1996): "Leptin: The Tale of an Obesity Gene". Diabetes. 45 (11): 1455–1462. DOI: 10.2337/diab.45.11.1455
  15. Ceddia, R.; William B.; Jr. William N.; Curi R. (2001): The Response of Skeletal Muscle to Leptin. Frontiers in Bioscience. 6, D90–97. DOI: 10.2741/ceddia
  16. Chehab, F.; Lim Me, F.; Lu, R. (1996): Correction of The Sterility Defect in Homozygous Obese Female Mice by Treatment with The Human Recombinant Leptin. Nat Genet; 12:318–320. DOI: 10.1038/ng0396-318
  17. Chelikani, P.K.; Ambrose, D.J.; Keisler, D.H.; Kennelly, J.J. (2009): Effects of Dietary Energy and Protein Density On Plasma Concentrations Of Leptin And Metabolic Hormones In Dairy Heifers. Journal of Dairy Science Volume 92, Issue 4, 1430–1441. https://doi.org/10.3168/jds.2008-1385
  18. Chilliard, Y.; Bonnet, M.; Delavaud, C.; Faulconnier, Y.; Leroux, C.; Djiane, J.; Bocquier, F. (2001): Leptin In Ruminant. Gene Expression In Adipose Tissue And Mammary Gland, And Regulation Of Plasma Concentration. Domestic Animal Endocrinologydomest. Nov; 21(4):271–95. Doi: 10.1016/S0739-7240(01)00124-2
  19. Chilliard, Y.; Delavaud, C.; Bonnet, M. (2005): Leptin Expression in Ruminants: Nutritional and Physiological Regulations in Relation With Energy Metabolism. Domest Anim Endocrinol. Jul;29(1):3–22. Doi: 10.1016/J.Domaniend.2005.02.026.
  20. Clarke, I.J.; Cummins, J.T. (1982): The Temporal Relationship Between Gonadotropin Releasing Hormone (GNRH) And Luteinizing Hormone (Lh) Secretion in Ovariectomized Ewes. Endocrinology; 111: 1737–1739. DOI: 10.1210/endo-111-5-1737
  21. Conde, J.; Scotece, M.; Gomez, R.; Lopez, V.; Gomez-Reino, J.J.; Lago, F.; Gualillo, O. (2011): Adipokines: Biofactors from White Adipose Tissue. A Complex Hub Among Inflammation, Metabolism, And Immunity. Biofactors, 37, 413–420. https://doi.org/10.1002/biof.185
  22. Córdova, B.; Morató, R.; De Frutos, C.; Bermejo-Álvarez, P.; Paramio, T. Gutiérrez-Adán, A.; Mogas, T. (2011): Effect of Leptin During in Vitro Maturation Of Prepubertal Calf Oocytes: Embryonic Development And Relative Mrna Abundances Of Genes Involved In Apoptosis And Oocyte Competence. Theriogenology, 76. 9, 1706–15. Doi: 10.1016/J.Theriogenology.2011.07.002
  23. Day, M.; Imakawa, K.; Garcia-Winder, M.; Zalesky, D.; Schanbacher, B.; Kittok, R.J.; Kinder, J. (1984): Endocrine Mechanisms of Puberty In Heifers: Estradiol Negative Feedback Regulation Of Luteinizing Hormone Secretion. Biol Reprod; 31:332–341. DOI: 10.1095/biolreprod31.2.332
  24. Davis Rincker, L.E.; Weber Nielsen, M.S.; Chapin, L.T.; Liesman, J.S.; Daniels, K.M.; Akers, R.M.; Vandehaar, M.J. (2008): Effects of Feeding Prepubertal Heifers a High-Energy Diet for Three, Six, Or Twelve Weeks On Mammary Growth and Composition. J. Dairy Sci., 91. 1926–1935. DOI: 10.3168/jds.2006-211
  25. Diaz-Torga, G.S.; Mejia, M.E.; Gonzalez-Iglesias, A.; Formia, N.; Becu-Villalobos, D.; Lacau-Mengido, I.M. (2001): Metabolic Cues for Puberty Onset In Free Grazing Holstein Heifers Naturally Infected With Nematodes. Theriogenology, 56, 111–122. DOI: 10.1016/s0093-691x(01)00547-7
  26. Dorling, A.A.; Todman, M.G.; Korach, K.S.; Herbison, A.E. (2003): Critical Role for Estrogen Receptor Alpha in Negative Feedback Regulation of Gonadotropin-Releasing Hormone Mrna Expression in The Female Mouse. Neuroendocrinology; 78:204–209. DOI: 10.1159/000073703
  27. Eitam, H.; Vaya, J.; Brosh, A.; Orlov, A.; Khatib, S.; Izhaki, I.; Shabtay, A. (2010): Differential Stress Responses Among Newly Received Calves: Variations In Reductant Capacity And Hsp Gene Expression. Cell Stress and Chaperones, 15, 865–876. Doi:10.1007/S12192-010-0195-9
  28. Franceschini, I.; Lomet, D.; Cateau, M.; Delsol, G.; Tillet, Y.; Caraty, A. (2006): Kisspeptin Immunoreactive Cells of the Ovine Preoptic Area and Arcuate Nucleus Co-Express Estrogen Receptor Alpha. Neurosci Lett; 401:225–230.
  29. Frayn, K.N.; Karpe, F.; Fielding, B.A.; Macdonald, I.A.; Coppack, S.W. (2003): Integrative Physiology of Human Adipose Tissue. Int. J. Obes. Relat. Metab. Disord., 27, 875–888. DOI: 10.1038/sj.ijo.0802326
  30. Friedman, J.M.; Halaas, J.L. (1998): Leptin and The Regulation of Body Weight in Mammals. Nature, 395(6704), 763–770.
  31. Frisch, R.E. (1985): Fatness, Menarche, And Female Fertility. Perspect Biol Med; 28. 611–633.
  32. Garcia, M.R., Amstalden, M., Williams, S.W., Stanko, R.L., Morrison, C.D., Keisler, D.H, Nizielski, S.E., Williams, G.L. (2002): Serum Leptin and Its Adipose Gene Expression During Pubertal Development, The Estrous Cycle, And Different Seasons in Cattle. J Anim Sci; 80:2158–2167. DOI: 10.2527/2002.8082158x
  33. Garcia, M.R., Amstalden, M., Morrison, C.D., Keisler, D.H., Williams, G.L. (2003): Age at Puberty, Total Fat and Conjugated Linoleic Acid Content of Carcass, And Circulating Metabolic Hormones in Beef Heifers Fed a Diet High In Linoleic Acid Beginning At Four Months Of Age. J. Anim. Sci., 81, 261–268.
  34. Gazal, O.; Leshin, L.; Stanko, R.; Thomas, M.; Keisler, D.; Anderson, L.; Williams, G. (1998): Gonadotropin-Releasing Hormone Secretion into Third-Ventricle Cerebrospinal Fluid of Cattle: Correspondence with The Tonic and Surge Release of Luteinizing Hormone and Its Tonic Inhibition by Suckling and Neuropeptide Y. Biol Reprod; 59:676–683. DOI: 10.1095/biolreprod59.3.676
  35. Gerrits, W.J.; Dijkstra, J.; France, J. (1997): Description of A Model Integrating Protein and Energy Metabolism in Preruminant Calves. Journal of Nutrition. 127(6), 1229–1242. https://Dx.Doi.Org/10.1093/Jn/127.6.1229
  36. Gholami, H.; Towhidi, A.; Zare, S.A.; Dirandeh, E. (2010): The Relationship of Plasma Leptin Concentration and Puberty in Holstein Bull Calves (Bos Taurus). Journal of Animal Physiology and Animal Nutrition. 94, 797–802. https://Doi.Org/10.1111/J.1439-0396.2009.00970.X
  37. Hamilton, B.S.; Paglia, D.; Kwan, A.Y.; Deitel, M. (1995): Increased Obese Mrna Expression in Omental Fat Cells from Massively Obese Humans. Nature Medicine. 1 (9): 953–956.
  38. Hayashi, H.; Yamakado, M.; Yamaguchi, M.; Kozakai, T. (2020): Leptin and Ghrelin Expressions in The Gastrointestinal Tracts Of Calves And Cows. J. Vet. Med. Sci. 82(4): 475–478, Doi: 10.1292/Jvms.19-0680
  39. Higashiyama, Y.; Abe, H.; Hayashi, M.; Hodate K. (2003): The Comparison Of Plasma Level And Mrna Expression Of Leptin From Japanese Black Steers And Holstein Steers Livestock Production Sciencelivestock Production Science, 81, Issues 2–3, June 2003, 247–255.
  40. Heiman, M.L.; Ahima, R.S.; Craft, L.S.; Schoner, B.; Stephens, T.W.; Flier, J.S. (1997): Leptin Inhibition of the Hypothalamic-Pituitary-Adrenal Axis in Response to Stress. Endocrinology. 138 (9): 3859–3863. DOI: 10.1210/endo.138.9.5366
  41. Houseknecht, K.L.; Portocarrero, C.P. (1998): Leptin and Its Receptors: Regulators of Whole-Body Energy Homeostasis. Domest Anim Endocrinol. Nov;15(6):457–75. Doi: 10.1016/S0739-7240(98)00035-6
  42. Jia, Z.; Zhang, J.; Wu, Z.; Tian, J. (2012): Leptin Enhances Maturation and Development of Calf Oocytes in Vitro. Reproduction In Domestic Animals = Zuchthygiene, 47 5, 718–23. https://Doi.Org/10.1111/J.1439-0531.2011.01949.X
  43. Kaya, A.; Sagirkaya, H.; Misirlioğlu, M.; Gümen, A.; Parrish, J.J.; Memili, E. (2017): Leptin and Igf-I Improve Bovine Embryo Quality in Vitro. Animal Reproduction, 14, 1151–1160. Doi:10.21451/1984-3143-Ar987
  44. Kawakita, Y.; Abe, H.; Hodate, K.; Iguchi, A.; Kobayashi, M.; Mori, T.; Kasai, K.; Tan, Y.; Kane, Y.; Mashiyama, H.; Asada, T.; Miyashige, T. (2001): The Relation Between Plasma Leptin Concentrations And Carcass Lipid Contents In Japanese Black Steers. Livestock Production Science. 73, Issue 1, 20 December 2001, 25–34. https://doi.org/10.1016/S0301-6226(01)00231-7
  45. Kelly, A.K.; Byrne, C.; Mcgee, M.; Perry, G.A.; Crowe, M.A.; Sauerwein, H.; Kenny, D.A. (2020): Effect of Calfhood Nutrition On Metabolic Hormones, Gonadotropins, And Estradiol Concentrations and On Reproductive Organ Development in Beef Heifer Calves. J Anim Sci. 98(10): Skaa310. Doi: 10.1093/Jas/Skaa310Kinder, J.E.; Day, M.; Kittok, R. (1987): Endocrine Regulation of Puberty in Cows and Ewes. J Reprod Fert Supp; 34:167–186. DOI: 10.1093/jas/skaa310
  46. Koldovský O. (1989): Search for Role of Milk-Borne Biologically Active Peptides for The Suckling; J. Nutr. 119(11):1543–51.
  47. Lacasse, P.; Block, E.; Petitclerc, D. (1994): Effect of Plane of Nutrition Before and During Gestation On the Concentration of Hormones in Dairy Heifers. J. Dairy Sci., 77. 439–445. DOI: 10.3168/jds.S0022-0302(94)76971-X
  48. Lammers, B.P.; Heinrichs, A.J. (2000): The Response of Altering the Ratio of Dietary Protein to Energy On Growth, Feed Efficiency, And Mammary Development in Rapidly Growing Prepubertal Heifers J. Dairy Sci., 83. 977–983.
  49. Lee, H.G.; Hong, Z.; Kim, M.K.; Kang, S.K.; Xu, C.X.; Cho, J.S.; Seo, K.S.; Roh, S.; Choi, Y.J. (2006): The Response of Plasma Leptin and Feed Intake to Growth Hormone Administration in Holstein Calves with Different Planes of Nutrition. Canadian Journal of Animal Science, 86, 225–233.Doi:10.4141/A05-009
  50. Lehman, M.N.; Merkley, C.M.; Coolen, L.M.; Goodman, R.L. (2010): Anatomy of The Kisspeptin Neural Network in Mammals. Brain Res; 1364:90–102.
  51. Lehman, M.N.; Coolen, L.M.; Goodman, R.L. (2010): Minireview: Kisspeptin/Neurokinin B/Dynorphin (Kndy) Cells of The Arcuate Nucleus: A Central Node in The Control of Gonadotropin-Releasing Hormone Secretion. Endocrinology; 151:3479–3489. DOI: 10.1210/en.2010-0022
  52. Lehman, M.N.; Hileman, S.M.; Goodman, R.L. (2013): Neuroanatomy of The Kisspeptin Signaling System in Mammals: Comparative and Developmental Aspects. In: Kisspeptin Signalingi Reproductive Biology, Springer, 27–62.
  53. Long, N.; Mccarty, K. (2023): 29 The Role of Leptin and Its Regulation in The Hypothalamus of Neonatal Calves. Journal Of Animal Science 101, Suppl. S3: 236–237. https://Doi.Org/10.1093/Jas/Skad281.285
  54. Lord, G.M.; Matarese, G.; Howard, J.K.; Baker, R.J.; Bloom, S.R.; Lechler, R.I. (1998): Leptin Modulates the T-Cell Immune Response and Reverses Starvation-Induced Immunosuppression. Nature. 394 (6696): 897–901. DOI: 10.1038/29795
  55. Mabuchi, T.; Yatsuya, H.; Tamakoshi, K.; Otsuka, R.; Nagasawa, N.; Zhang, H. (2005): Association Between Serum Leptin Concentration and White Blood Cell Count in Middle-Aged Japanese Men and Women. Diabetes/Metabolism Research and Reviews. 21 (5): 441–447.
  56. Madej, T.; Boguski, M.S.; Bryant, S.H. (1995): Threading Analysis Suggests That the Obese Gene Product May Be a Helical Cytokine. Febs Letters. 373 (1): 13–18. https://doi.org/10.1016/0014-5793(95)00977-h
  57. Madeja, Z.E.; Warzych, E.; Peippo, J.; Lechniak, D.; Switonski, M. (2009): Gene Expression and Protein Distribution of Leptin and Its Receptor in Bovine Oocytes and Preattachment Embryos Produced in Vitro. Animal: An International Journal of Animal Bioscience, 3(4), 568–78. doi:10.1017/S1751731108003741
  58. Mayer, C.; Acosta-Martinez, M.; Dubois, S.L.; Wolfe, A.; Radovick, S.; Boehm, U.; Levine, J.E. (2010): Timing and Completion of Puberty in Female Mice Depend On Estrogen Receptor Α- Signaling in Kisspeptin Neurons. Proc Natl Acad Sci; 107:22693–22698.
  59. Morris, C.; Mccarty, K.J.; Long, N. (2020): 59 Effects of Exogenous Glucocorticoid Administration On Leptin Concentrations in Perinatal Dairy Bull Calves. Journal of Animal Science, 98(Suppl 2), 37. https://Doi.Org/10.1093/Jas/Skz397.084
  60. Mukherjee, A.; Samanta, I.; Joardar, S.N. (2023): Biology and Significance of Leptin in Animal Production: A Perspective. Indian Journal Of Animal Sciences, 93 (12): 1131–1139, /Review Article https://Doi.Org/10.56093/Ijans.V93i12.116875
  61. Long, N.; Mccarty K.J. (2023): The Role Of Leptin And Its Regulation In The Hypothalamus Of Neonatal Calves, Journal Of Animal Science, 101, 3, 236–237. https://Doi.Org/10.1093/Jas/Skad281.285
  62. Nedergaard, J.; Bengtsson, T.; Cannon, B. (2007): Unexpected Evidence for Active Brown Adipose Tissue in Adult Humans. Am. J. Physiol. Endocrinol. Metab., 293, E444–E452. DOI: 10.1152/ajpendo.00691.2006
  63. Nonaka, S.; Hashizume, T.; Kasuya, E. (2006): Effects of Intracerebroventricular Injections of Leptin On the Release of Luteinizing Hormone and Growth Hormone in Castrated Calves. Animal Science Journal, 77, 196–200. Doi:10.1111/J.1740-0929.2006. 00337.X
  64. Park, A.; Kim, W.K.; Bae, K.H. (2014): Distinction of White, Beige and Brown Adipocytes Derived from Mesenchymal Stem Cells. World J. Stem Cells, 6, 33–42.
  65. Petrovic, N.; Walden, T.B.; Shabalina, I.G.; Timmons, J.A.; Cannon, B.; Nedergaard, J. (2010): Chronic Peroxisome Proliferator-Activated Receptor Gamma (Ppargamma) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, Ucp1-Containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes. J. Biol. Chem., 285, 7153–7164. DOI: 10.1074/jbc.M109.053942
  66. Pinotti, L.; Rosi, F. (2006): Leptin in Bovine Colostrum and Milk. Horm. Metab. Res.; 38(2): 89–93. Doi: 10.1055/S-2006-925119
  67. Perrier, S.; Caldefie-Chézet, F.; Vasson, M.P. (2009): Il-1 Family in Breast Cancer: Potential Interplay with Leptin and Other Adipocytokines. Febs Letters. 583 (2): 259–265.
  68. Pond, C.M. (1992): An Evolutionary and Functional View of Mammalian Adipose Tissue. Proc. Nutr. Soc., 51, 367–377. DOI: 10.1079/pns19920050
  69. Redmond, J.S.; Macedo, G.F.; Velez, I.C.; Caraty, A.; Williams, G.; Amstalden, M. (2011): Kisspeptin Activates the Hypothalamic–Adenohypophyseal–Gonadal Axis in Prepubertal Ewe Lambs. Reproduction; 141:541–548.
  70. Quennell, J.H.; Mulligan, A.C.; Tups, A.; Liu, X.; Phipps, S.J.; Kemp, C.J.; Herbison, A.E.; Grattan, D.R.; Anderson, G.M. (2009): Leptin Indirectly Regulates Gonadotropin-Releasing Hormone Neuronal Function. Endocrinology. 150. 2805–2812. DOI: 10.1210/en.2008-1693
  71. Quigley, J.D. (2019): Symposium Review: Re-Evaluation Of National Research Council Energy Estimates In Calf Starters. J. Dairy Sci. 102:3674–3683 https://Doi.Org/10.3168/Jds.2018-15367
  72. Ryan K.; Foster, D. (1980): Neuroendocrine Mechanisms Involved in Onset of Puberty in The Female: Concepts Derived from The Lamb. Federation Proceedings, 7, 2372–2377.
  73. Roubos, E.W.; Dahmen, M.; Kozicz, T.; Xu, L. (2012). Leptin and The Hypothalamo-Pituitary-Adrenal Stress Axis. General and Comparative Endocrinology, 177. 1, 28–36. Doi: 10.1016/J.Ygcen.2012.01.009
  74. Shen, L.; Zhu, Y.; Xiao, J.; Qian, B.; Jiang, T.; Deng, J.; Peng, G.; Yu, S.; Cao, S.; Zuo, Z.; Ma, X.; Zhong, Z.; Ren, Z.; Wang, Y.; Zhou, Z.; Liu, H.; Zong, X.; Hu, Y. (2020): Relationships Between Placental Adiponectin, Leptin, Visfatin and Resistin and Birthweight In Cattle Reproduction, Fertility And Development. 32. (4) 402–408.
  75. Stepien, M.; Rosniak-Bak, K.; Paradowski, M.; Misztal, M.; Kujawski, K.; Banach, M.; Rysz, J. (2011): Waist Circumference, Ghrelin and Selected Adipose Tissue-Derived Adipokines as Predictors of Insulin Resistance in Obese Patients: Preliminary Results. Med. Sci. Monit., 17, Pr13–Pr18. DOI: 10.12659/msm.882030
  76. Tanaka, T.; Ozawa, T.; Hoshino, K.; Mori, Y. (1995): Changes in The Gonadotropin-Releasing Hormone Pulse Generator Activity During the Estrous Cycle in The Goat. Neuroendocrinology. 62:553–561.
  77. Tahreer, M.; Al-Thuwaini, Fadhil, A.; Rhadi, A.; Kadhim, H. (2024): Adipokines And Reproduction In Ruminant Livestock J-Stage. Reviews In Agricultural Science. 7-Vol. 12. 13–23. https://Doi.Org/10.7831/Ras.12.0_13
  78. Tonon, F.; Di Bella, S.; Giudici, F.; Zerbato, V.; Segat, L.; Koncan, R.; Salvador, J (Ed.). (2022): Discriminatory Value of Adiponectin to Leptin Ratio for Covid-19 Pneumonia. International Journal of Endocrinology. 9908450.
  79. Van Niekerk, J.K.; Fischer-Tlustos, A.J.; Wilms, J.N.; Hare, K.S.; Welboren, A.C.; Lopez, A.J.; Yohe, T.T.; Cangiano, L.R.; Leal, L.N.; Steele, M.A. (2021): Adsa Foundation Scholar Award: New Frontiers in Calf and Heifer Nutrition—From Conception to Puberty. J. Dairy Sci. 104:8341–8362 https://Doi.Org/10.3168/Jds.2020-20004
  80. Wabitsch, M.; Jensen, P.B.; Blum, W.F.; Christoffersen, C.T.; Englaro, P.; Heinze, E. (1996): Insulin and Cortisol Promote Leptin Production in Cultured Human Fat Cells. Diabetes. 10. 1435–8. DOI: 10.2337/diab.45.10.1435
  81. Williams, G.; Amstalden, M.; Garcia, M.; Stanko, R.; Nizielski, S.; Morrison, C.; Keisler, D. (2002): Leptin and Its Role in The Central Regulation of Reproduction in Cattle. Domest Anim Reprod; 23:339–349.
  82. Williams, Gl.; Alves, Br.; Cardoso, R.C. (2014): Female Puberty: Nutrition and Endocrinology. In M.K. Skinner (Ed) Encyclopedia of Reproduction, 2nd Ed. Vol 3.; Elsevier, New York, Ny Usa
  83. Yelich, J.V.; Wettemann, R.P.; Dolezal, H.G.; Lusby, K.S.; Bishop, D.K.; Spicerl, J. (1995): Effects of Growth Rate On Carcass Composition and Lipid Partitioning at Puberty and Growth Hormone, Insulin-Like Growth Factor I, Insulin, And Metabolites Before Puberty In Beef Heifers. J.Anim. Sci., 73, 2390–2405. DOI: 10.2527/1995.7382390x
  84. Zieba, D.A.; Amstalden, M.; William, G.L. (2005): Regulatory Roles of Leptin in Reproduction and Metabolism: A Comparative Review. Domest. Anim. Endocrinol., 29, 166–185.
  85. Zhang, Y.; Proenca, R.; Maffei, M.; Barone, M.; Leopold, L.; Friedman, J.M. (1994): Positional Cloning of the Mouse Obese Gene and Its Human Homologue. Nature, 372, 425–432.
  86. Zhang, F.; Chen, Y.; Heiman, M.; Dimarchi, R. (2005): Leptin: Structure, Function and Biology. Vitam Horm; 71:345–372. DOI: 10.1016/S0083-6729(05)71012-8