The cholera epidemic of 1831 came to Hungary from Galicia that belonged to the Austrian Empire. The epidemic broke out in Debrecen on 24th July 1831, and claimed thelives of 7.4% of the city's population, or more precisely, 2152 people. The resources detailing the events of the Cholera epidemic in Debrecen can be read in the Hajdú-Bihar County Archives of the Hungarian National Archives. This study presents the report of József Zsebők that shows in more detail the local event from the outburst of the epidemic to the release of the quarantine in October. The highly detailed report by Ádám Reviczky, General Chancellor, presented on 9th December 1831, nicely reflects what the contemporary medicine thought about the cholera disease and how they tried to cure it. This resource is essential not only from a point of view of local history, but also from a medical historical point of view, as – besides exploring the characteristics of the disease – it provides an authentic picture of the medical conditions, medical treatments, and even of the medicines of the time. In the bibliography, modern transcription was used, preserving the characteristic features of language or dialect.