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• Formulation and Evaluation of Topical Dosage Forms Containing Niacinamide

  Péter Pártos

  Helia Bakhtiari

  Ágota Pető

  Dóra Kósa

  Views:

  153

  This study focuses on the formulation and evaluation of a cream and gel containing niacinamide, a commonly used active ingredient in skincare. Niacinamide, a water-soluble form of vitamin B₃, is known for its ability to strengthen the skin barrier, reduce inflammation, and regulate sebum production. Two formulations were developed: a cream composed of cetyl stearyl alcohol, stearic acid, glycerol, isopropyl myristate, sucrose ester, propylene glycol, distilled water, and niacinamide; and a gel formulated with glycerol, carbopol, triethanolamine, distilled water, and niacinamide. The cream, an oil-in-water emulsion, was designed for rich, long-lasting moisturization, while the gel was intended as a lightweight, water-based alternative. Both formulations were analyzed for pH, texture, dissolution and potential toxicological properties. The results revealed distinct differences: the cream provided superior hydration and barrier repair, whereas the gel offered a non-greasy, refreshing texture more suitable for oily or combination skin types. These findings highlight the versatility of niacinamide in topical applications and establish a foundation for further research on its efficacy in different delivery systems.

• Comparative study of different gel bases with herbal and synthetic active substance

  Zsolt Hosszú

  Shahab Sharafi

  Sahand Emadzadeh

  Dóra Kósa

  Ádám Haimhoffer

  Fruzsina Nacsa

  Ágota Pető

  Views:

  67

  This study compares two gel bases in which either natural or synthetic active substances are incorporated: Philadelphus coronarius flower extract and BGP-15. The preparations were evaluated for texture analysis, in vitro drug release and pH characteristics. Gels were formulated using Carbopol 940 or hydroxypropyl methylcellulose (HPMC) as gelling agents. Texture analysis revealed comparable mechanical properties with slight increases in firmness upon incorporation of active substances. In vitro release studies demonstrated rapid early release for both gel bases, with Philadelphus coronarius reaching approximately 27% release at 180 minutes and BGP-15 achieving ~26% release. The findings support the dermal applicability of both agents and highlight their potential roles in natural and synthetic therapeutic skin preparations.