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Formulation and Evaluation of Topical Dosage Forms Containing Niacinamide

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2025-12-18
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Copyright (c) 2025 Péter Pártos, Helia Bakhtiari, Ágota Pető, Dóra Kósa (Author)

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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Pártos P, Bakhtiari H, Pető Á, Kósa D. Formulation and Evaluation of Topical Dosage Forms Containing Niacinamide. DRem [Internet]. 2025 Dec. 18 [cited 2025 Dec. 23];2(1). Available from: https://ojs.lib.unideb.hu/de-remediis/article/view/16419
Received 2025-11-24
Accepted 2025-12-15
Published 2025-12-18
Abstract

This study focuses on the formulation and evaluation of a cream and gel containing niacinamide, a commonly used active ingredient in skincare. Niacinamide, a water-soluble form of vitamin B₃, is known for its ability to strengthen the skin barrier, reduce inflammation, and regulate sebum production. Two formulations were developed: a cream composed of cetyl stearyl alcohol, stearic acid, glycerol, isopropyl myristate, sucrose ester, propylene glycol, distilled water, and niacinamide; and a gel formulated with glycerol, carbopol, triethanolamine, distilled water, and niacinamide. The cream, an oil-in-water emulsion, was designed for rich, long-lasting moisturization, while the gel was intended as a lightweight, water-based alternative. Both formulations were analyzed for pH, texture, dissolution and potential toxicological properties. The results revealed distinct differences: the cream provided superior hydration and barrier repair, whereas the gel offered a non-greasy, refreshing texture more suitable for oily or combination skin types. These findings highlight the versatility of niacinamide in topical applications and establish a foundation for further research on its efficacy in different delivery systems.

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