About the Journal
| De Remediis (About Remedies) as the official scientific journal of the Faculty of Pharmacy, University of Debrecen, is a peer-reviewed biannual (one issue every 6 months) diamond open-access journal that provides publication platform for a wide range of experimental and theoretical works in the field of pharmaceutical sciences. Covered topics include pharmaceutical technology, pharmaceutical chemistry, biopharmaceutics, pharmacology, pharmacognosy, phytochemistry, phytopharmacology, molecular and cell biology and development of cosmetics and nutraceuticals. The journal welcomes publications reporting the synthesis and examination of new active substances, formulation and process development, the investigation of the biological and molecular effects of individual active substances and their pharmacokinetics, as well as the development of new types of drug carrier systems and nanotechnology. Our aim is to encourage researchers, lecturers and students working in any field of pharmacy and connected sciences to present their experimental and theoretical results in detail. Above the regular issues, Special issues might be published covering especially interesting topics, under the supervision of the offical editorial team. |
Vol. 2 No. 2 (2026) Current Issue
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Articles
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Comparative Evaluation of Solubilization Strategies for an ABCG2 Transporter Inhibitor
Views:16Poor aqueous solubility remains one of the major challenges in the development of orally administered drugs, particularly for lipophilic molecules such as ABCG2 transporter inhibitors. These compounds possess high molecular weight, significant lipophilicity, and limited water solubility, which restrict their bioavailability and therapeutic application. This study aimed to enhance the solubility of a model ABCG2 inhibitor using different solubilization techniques, including co-grinding with hydroxypropyl-β-cyclodextrin (HP-β-CD) or polyvinylpyrrolidone (PVP) and micellar solubilization using nonionic surfactants. Each formulation was optimized and characterized for drug loading, equilibrium solubility and dissolution behavior under simulated gastrointestinal conditions. The micellar formulation exhibited the highest solubilization efficiency, The HP-β-CD complex and PVP co-grinding dispersions also resulted in notable enhancement compared to the pure drug. These findings highlight the potential of simple formulation strategies to overcome solubility limitations of ABCG2 inhibitors and improve their oral bioavailability.
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