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• Comparative study of different gel bases with herbal and synthetic active substance

  Zsolt Hosszú

  Shahab Sharafi

  Sahand Emadzadeh

  Dóra Kósa

  Ádám Haimhoffer

  Fruzsina Nacsa

  Ágota Pető

  Views:

  26

  This study compares two gel bases in which either natural or synthetic active substances are incorporated: Philadelphus coronarius flower extract and BGP-15. The preparations were evaluated for texture analysis, in vitro drug release and pH characteristics. Gels were formulated using Carbopol 940 or hydroxypropyl methylcellulose (HPMC) as gelling agents. Texture analysis revealed comparable mechanical properties with slight increases in firmness upon incorporation of active substances. In vitro release studies demonstrated rapid early release for both gel bases, with Philadelphus coronarius reaching approximately 27% release at 180 minutes and BGP-15 achieving ~26% release. The findings support the dermal applicability of both agents and highlight their potential roles in natural and synthetic therapeutic skin preparations.

• Formulation and investigation of Lactobacillus rhamnosus cek-R1 filled alginate microspheres with different excipients

  Pálma Fehér

  Boglárka Papp

  Liza Józsa

  Dávid Sinka

  Eszter Fidrus

  Fruzsina Nacsa

  Ildikó Bácskay

  Gábor Kardos

  Views:

  226

  Microspheres are spherical particles containing the active substance, in our case bacterial probiotic strain Lactobacillus rhamnosus (L. rhamnosus), in an individually coated form. L. rhamnosus is a natural constituent of the human intestinal flora and is known to improve immune function, enhance healing of the intestinal mucosa, reduce inflammation, bloating and diarrhoea.  

  The aim of our experimental work was to formulate sodium alginate microspheres containing L. rhamnosus bacterial strain as active ingredient and prebiotic (galactooligosaccharide, pectin, inulin). The microspheres were formulated using Büchi Encapsulator equipment, after which the entrapment efficiency was measured. The lyophilized product was filled into hydroxypropylmethylcellulose (HPMC) capsules and was subjected to a dissolution assay using Erweka equipment. The number of viable L. rhamnosus was determined from samples of the dissolution fluid.  The microspheres are lyophilised to improve shelf-life and facilitate filling into traditional capsules. The number of viable bacteria in the lyophilizate was determined by inoculation on medium and standard microdilution test. Microspheres containing different compositions of pro- and prebiotics were formulated, and their antioxidant capacity was detected by 2,2-diphenyl-l-1-picrylhydrazyl (DPPH). We tested the anti-inflammatory effect of the microspheres using human IL-4 ELISA Kit on colon adenocarcinoma (CaCo-2) cell line.