In this study, I would like to describe the activities of disinfection health guards and delousing patrols. The research was based on documents kept in the Beregszász Department of the Regional State Archives of the Transcarpathian Oblast, and on the collections of the Hungarian National Archives and the National Széchényi Library. The disinfectant health guards performed a preventive, monitoring, control and executive service in public health, epidemiological, trade fair and market policing matters referred to the authority of the district. Delousing patrols often performed their duties in the affected settlements, and continued to be active – during the epidemic-free period – for prevention purposes. Despite the disinfectant work done under difficult conditions, the expected results were achieved, as shown by the reduction in the number of infections.