The present work is mainly directed to discuss sensitivity of climate changes upon the irrigation demand for grape crop in Egypt. The Penman Monteith equation was used to calculate reference Evapotranspiration (ETo) under current and future climate for the two locations (El Menya and El Beheira). The historical climate data for ten years from (...2000 – 2010) was used as current climate to calculate irrigation requirement for grape crop under Egyptian conditions. Two climate changes scenarios have been applied as changes in temperature. The first scenario supposed that increasing in temperature of 1.5°C would happen, and the second scenario supposed that increasing of 3.5°C would happen to calculate reference Evapotranspiration and irrigation requirement for future climate. The results showed that the evapotranspiration and irrigation requirement for grape crop at El Menya location higher than El Beheira location. Irrigation demand for grape plant under two climate changes scenario will increase in El Menya and El Beheira locations. El Menya location will take the highest irrigation demand under climate changes. Therefore, possible adaptation countermeasures should be developed to mitigate the negative effects of climate changes for the sustainable development of agro-ecosystems in Egypt.