This paper gives an account of biogeographically interesting plant species of the traditional ethnographic region Sălaj (in Hungarian: “Szilágyság”, NW Romania). The flora of the region, which is situated between the Transylvanian Basin and the eastern part of the Great Hungarian Plain, contains, besides the prevailing European species, a significant percentage of plant species from different biogeographic regions. Among these we noticed the continental species of eastern origin, as well as southern Sub-Mediterranean species broadly distributed in this area. A significant number of other interesting species is further represented by the endemic and sub-endemic Carpathian (Aconitum moldavicum Hacq., Symphytum cordatum Waldst. & Kit.), Transylvanian (Cephalaria radiata Griseb. & Schenk, Onosma pseudoarenaria Schur subsp. pseudoarenaria), Dacian (Helleborus purpurascens Waldst. & Kit., Phyteuma tetramerum Schur) and Pannonian (Centaurea sadleriana Janka), species, which occur in very different habitats.