The Department of Dermatology at the University of Debrecen celebrated its 100th anniversary in 2021. However, the year 2021 did not allow us celebrate this important anniversary properly, due to the COVID pandemic, so the festive meeting in honor of the Centenary and this commemorative article were organized and completed in the spring of 2023. History of the past 100 years of the Department of Dermatology is presented reviewing the main developmental steps in patient care, education, and research, remembering the legacy of our former colleagues and directors, furthermore to provide an opportunity to all employees of the University and independent readers to gain insights into this interesting, more than hundred years’ medical history of dermatology in Debrecen.