No. 2 (2020)
Articles

Effects of bioactive plant extracts on immune-related gene expression of common carp (Cyprinus carpio)

Published December 1, 2020
Brigitta Csernus
1University of Debrecen, Faculty of Agricultural and Food Sciences and Environmental Management, Institute of Animal Science, Biotechnology and Nature Conservation, Department of Animal Science
Sándor Bíró
3University of Debrecen, Faculty of Medicine, Department of Human Genetics, Debrecen
László Stündl
University of Debrecen, Faculty of Agricultural and Food Sciences and Environmental Management, Institute of Food Technology, Debrecen
Judit Remenyik
University of Debrecen, Faculty of Agricultural and Food Sciences and Environmental Management, Institute of Food Technology, Debrecen
Péter Bai
5University of Debrecen, Faculty of Medicine, Department of Medical Chemistry, Debrecen
Milán Fehér
University of Debrecen, Faculty of Agricultural and Food Sciences and Environmental Management, Institute of Animal Science, Biotechnology and Nature Conservation, Department of Animal Science, Debrecen
Dániel Minya
University of Debrecen, Faculty of Agricultural and Food Sciences and Environmental Management, Institute of Animal Science, Biotechnology and Nature Conservation, Department of Animal Science, Debrecen, University of Debrecen, Doctoral School of Animal Science, Debrecen
Levente Czeglédi
University of Debrecen, Faculty of Agricultural and Food Sciences and Environmental Management, Institute of Animal Science, Biotechnology and Nature Conservation, Department of Animal Science, Debrecen
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APA

Csernus, B., Bíró, S., Stündl, L., Remenyik, J., Bai, P., Fehér, M., Minya, D., & Czeglédi, L. (2020). Effects of bioactive plant extracts on immune-related gene expression of common carp (Cyprinus carpio) . Acta Agraria Debreceniensis, (2), 49-56. https://doi.org/10.34101/ACTAAGRAR/2/8260

 In recent years, intensive fish farming has led to an outbreak of several diseases, and the health status of fish can affect the economy of aquaculture. Since fish health and intestinal health are in correlation, it may also have an impact on immunity. Accordingly, many natural feed additives are being used to improve immune functions. In our study, carotenoids, oligosaccharides, and anthocyanins were applied at 1 m/m% in feed to investigate their effects on cytokines, such as interleukin-1β (IL-1β), interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), and interferon regulatory factor-1 (IRF-1) in spleen and mid-intestine of 6 months old carp. Gene expression analysis was carried out to examine IL-1β, IL-8, TNF-α, and IRF-1 mRNA levels in fish spleen and mid-intestine. The gene expression level of pro-inflammatory IL-1β decreased in the mid-intestine of carotenoid-fed carp compared to anthocyanin supplemented group, but the effects of the bioactive plant extracts were not observed on the examined cytokines compared to control fish.

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