This paper offers a reading of Ali Smith’s 2014 novel, How to Be Both, in the context of Aby Warburg’s iconological interpretation of the frescoes by Francesco del Cossa in the Palazzo Schifanoia in Ferrara. Having reconstructed the story behind the creation, attribution, and reading of the frescoes, the paper argues for recognizing them as a major source of inspiration for Smith’s narrative. Furthermore, the principle of “bothness” is recognized as the novel’s foremost concern; both formal—pertaining to paratextual, graphic, and typeset solutions employed by the narrative—and thematic. With the help of Warburg’s concept of Nachleben and his proposition of traveling forms and images, How to Be Both is ultimately identified as a novel vitally indebted to Warburg’s theoretical and interpretative model. Last but not least, it testifies to the “after-life” of Warburg’s ideas. (RK, WSZ)