The medical training at the Faculty of Medicine of the Debrecen Hungarian Royal University started in 1921. The Department of Mental and Neurological Diseases began its operation in 1921 at the Magoss György Square (current Bem square) under the leadership of László Benedek. The clinic moved to its new building at the Nagyerdő in 1927. László Benedek was succeeded by István Somogyi in 1937, and by Kálmán Sántha in 1938. Sántha’s main merit was the introduction of neurosurgery procedures and the establishment of the neurosurgery unit in Debrecen. He was convicted with fictional political accusations, and exiled to Balassagyarmat in 1951. Although rehabilitated in 1956, he was unable to return to the clinic in Debrecen. While Sántha worked at Balassagyarmat, the clinic was run by Sándor Rusz. Between 1957 and 1967 Pál Juhász had been the director of the clinic, who established a neurosis unit and EEG laboratory. After a two-year transitional period, László Molnár was appointed to be head of the clinic in 1969. Realizing that stroke is a public health issue, he was among the first who established a cerebrovascular unit in Europe. He was succeeded by László Csiba, who led the clinic between 1992 and 2017. The separation of the Department of Neurology and Department of Psychiaty in 1992, as well as the relocation of the Department of Neurology to the Auguszta area took place during his leadership. Professor Csiba established an excellent stroke center, and introduced reperfusion therapies in Debrecen. Currently, the Department of Neurology is headed by László Oláh.