Innovative Pharmacotherpy

Investigation of the cellular internalization of hydroxypropyl-beta-cyclodextrin and its effects on lysosomes

Published:
2023-07-15
Authors
View
Keywords
License

Copyright (c) 2023 Health Innovation Review

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Az Egészségügyi Innovációs Szemle folyóiratban megjelenő cikkek szabadon megoszthatók, másolhatók az anyagok bármilyen megjelenési formájában a "CC Attribution-NonCommercial-NoDerivatives 4.0" licenszben szereplő szabályok betartásával.

A cikkek változtatás nélkül terjeszthetők, és kereskedelmi felhasználásuk tilos.

How To Cite
Selected Style: APA
Rusznyák, Ágnes, Réti-Nagy, K., Váradi, J., Bácskay, I., Vecsernyés, M., & Fenyvesi, F. (2023). Investigation of the cellular internalization of hydroxypropyl-beta-cyclodextrin and its effects on lysosomes. Health Innovation Review, 2(2), 57-64. https://doi.org/10.56626/egis.v2i2.12924
Abstract

Cyclodextrins are widely used excipients to increase water solubility and bioavailability of lipophilic drugs. Our research group previously showed that cyclodextrins are able to enter Caco-2 intestinal epithelial cells by endocytosis, however, the cellular internalization and intracellular effects in the case of different cells have not been investigated yet. In addition, 2-hydroxypropyl-beta-cyclodextrin (HPBCD) is a potential molecule for the treatment of Niemann Pick syndrome type C due to its cholesterol complexing properties. The aim of our work is to investigate and compare the cellular internalization of HPBCD and its effect on lysosomes on Caco-2 intestinal epithelial, HeLa cervical epithelial and hCMEC/D3 brain endothelial cells.