Nowadays, due to their special properties, nanomaterials are gaining more and more interest and their industrial application is increasing. Their specific properties are mainly due to the fact that the main characteristics of nanomaterials are not always the same as the normal size range of the same material. While these materials fulfill an important new function in the industry, their interactions with the environment and biological organisms are becoming increasingly unpredictable, increasing uncertainty, for example, in their application to human safety. Due to the very rapid technological development, these substances have been used much earlier than the legal framework for their application could have developed, and therefore a binding regulation on the use of nanomaterials is currently not available. At this moment, the manufacturer of the nanomaterial is responsible for the safety of the products. Of course, owever, chemical safety legislation and standards provide an excellent basis for their management, but due to their specific properties, novelty and lack of knowledge of the mechanism of action, risk assessment can still be a challenge for the practitioner.