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• Formulation of Novel Liquid Crystal (LC) Formulations with Skin-Permeation-Enhancing Abilities of Plantago lanceolata (PL) Extract and Their Assessment on HaCaT Cells

  Zoltán Ujhelyi

  Views:

  115

  Exposure to reactive oxygen species can easily result in serious diseases, such as hyperproliferative skin disorders or skin cancer. Herbal extracts are widely used as antioxidant sources in different compositions. The importance of antioxidant therapy in inflammatory conditions has increased. Innovative formulations can be used to improve the effects of these phytopharmacons. The bioactive compounds of Plantago lanceolata (PL) possess different effects, such as anti-inflammatory, antioxidant, and bactericidal pharmacological effects. The objective of this study was to formulate novel liquid crystal (LC) compositions to protect Plantago lanceolata extract from hydrolysis and to improve its effect. Since safety is an important aspect of pharmaceutical formulations, the biological properties of applied excipients and blends were evaluated using assorted in vitro methods on HaCaT cells. According to the antecedent toxicity screening evaluation, three surfactants were selected (Gelucire 44/14, Labrasol, and Lauroglycol 90) for the formulation. The dissolution rate of PL from the PL-LC systems was evaluated using a Franz diffusion chamber apparatus. The antioxidant properties of the PL-LC systems were evaluated with 2,2-diphenyl-1-picrylhydrazyl (DPPH) and malondialdehyde (MDA) assessments. Our results suggest that these compositions use a nontraditional, rapid-permeation pathway for the delivery of drugs, as the applied penetration enhancers reversibly alter the barrier properties of the outer stratum corneum. These excipients can be safe and highly tolerable thus, they could improve the patient’s experience and promote adherence.

• School health program in Debrecen: health from the beginning

  65-74

  Csaba Papp

  Views:

  177

  With the support of the Debrecen County Municipality at Pósa Street No. 1., a nationwide unique school health program has been launched at the Health Development Institute, which establishment was inaugurated on the 11th of October 2019 as part of the Clinical Center of the University of Debrecen. As it is well known, within the framework of the school health care program, operating on the basis of NM decrees 26/1997. (IX. 3.), 51/1997. (XII. 18.) and 33/1998. (VI. 24.), primary and secondary school students participate in mandatory screening tests every two years - during the so-called "indicator" years (the 2nd, 4th, 6th, 8th, 10th and 12th). The goal of DAEFI is to centralise school health objectives and additional examinations as part of a particular model program. After the coronavirus epidemic, the 2021/2022 academic year was the first full term when the screenings defined by the legislation could take place with the coordination of DAEFI, which preventive measures, with parental consent, were supplemented with an EKG examination as well as Prevention Lectures. We are now presenting the experiences of this first year.