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• Role of cyclodextrins in therapeutic strategies of COVID-19

  Katalin Réti-Nagy

  Ildikó Bácskay

  Miklós Vecsernyés

  Ferenc Fenyvesi

  Views:

  131

  Since the emergence of the SARS-CoV-2 virus in late 2019, several therapeutic possibilities have appeared to treat patients who are often in severe condition due to the pathogen. As more information  becomes available about the virus, the therapeutic strategies can be more specific. Cyclodextrins are well known molecules in the pharmaceutical industry. Due to their special structure they can be widely used in drug development. One of our main research topic is the application of cyclodextrins, so considering the current pandemic situation, it was relevant for us to summarize the role of cyclodextrin molecules in the therapy of COVID-19 disease. In the course of our literary research, we have found many interesting theories and promising developments.

• Investigation of the cellular internalization of hydroxypropyl-beta-cyclodextrin and its effects on lysosomes

  57-64

  Ágnes Rusznyák

  Katalin Réti-Nagy

  Judit Váradi

  Ildikó Bácskay

  Miklós Vecsernyés

  Ferenc Fenyvesi

  Views:

  74

  Cyclodextrins are widely used excipients to increase water solubility and bioavailability of lipophilic drugs. Our research group previously showed that cyclodextrins are able to enter Caco-2 intestinal epithelial cells by endocytosis, however, the cellular internalization and intracellular effects in the case of different cells have not been investigated yet. In addition, 2-hydroxypropyl-beta-cyclodextrin (HPBCD) is a potential molecule for the treatment of Niemann Pick syndrome type C due to its cholesterol complexing properties. The aim of our work is to investigate and compare the cellular internalization of HPBCD and its effect on lysosomes on Caco-2 intestinal epithelial, HeLa cervical epithelial and hCMEC/D3 brain endothelial cells.