Search

Search Results

• Hot-melt extrusion – filament manufacturing coupled with fused deposition modeling for 3D printed pharmaceuticals -a brief review

  Petra Arany

  Bence Vámosi

  Ildikó Bácskay

  Pálma Fehér

  Views:

  168

  3D printing or additive manufacturing are conquering many industrial fields, just as the pharmaceutical industry. There are several types of additive manufacturing processes, however one technology, the fused deposition modeling is outstanding in the pharmaceutical field. Fused deposition modelling uses filaments for printing. These filaments are made out of polymers that has diverse properties, suitable for containing active pharmaceutical ingredients for various usages. These filaments can be produced by hot-melt extrusion process, that the pharmaceutical field already uses for several formulations. In order to get a useable filament, we need more machines than just the extruder. Through the process, the feeder, the conveyor and the winder machines are necessary to get the desired homogeneity, filament diameter, and a ready to use filament roll to easily couple hot melt extrusion with fused deposition modeling. Polymers for pharmaceutical usage are already exists, including polyethylene glycols, polylactic acids, hydroxypropyl cellulose and many more. Finding polymers that has the appropriate rheological properties, heat- and chemical stability to apply in hot-melt extrusion-, and fused deposition modeling process, turned out to be challenging, but not impossible task. In conclusion, hot melt extrusion is a reliable method to produce polymer filaments for fused deposition modeling, that is suitable to print pharmaceuticals, however, the knowledge of this field is continuously expanding, thanks to the researchers around the world.

• Personalized 3D-Printed Gastroretentive Drug Forms with Metronidazole

  Réka Révész

  Akay Dogan Mengenli

  Mónika Béres

  Petra Arany

  Ádám Haimhoffer

  Views:

  16

  3D printing is increasingly recognized as a versatile manufacturing approach, enabling the production of devices that are difficult or costly to fabricate using conventional methods. In this study, we aimed to develop a hollow, 3D-printed capsule designed for incorporation of a molten matrix containing an active pharmaceutical ingredient, and to evaluate its potential for gastric retention through controlled drug release. Capsule shells were fabricated from polylactic acid using fused deposition modeling and subsequently filled with polyethylene glycol-based melts. Micro-CT was employed to assess internal structure and integrity. Drug release profiles were measured for different matrix compositions, and texture as well as compositional analyses were performed on both filled and unfilled capsules. Our findings demonstrate that the 3D-printed PLA shells provide sufficient mechanical strength and, depending on the matrix composition, enable controlled, zero-order drug release for up to five hours. These results highlight the potential of 3D-printed capsules as a customizable, gastro-retentive drug delivery system, offering opportunities for personalized therapies.