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Process optimization for in-house, lab scale pellet bead production using twin-screw extruder and spheroniser
Views:158Multiparticulate dosage forms are becoming more popular than single-unit forms because they offer benefits such as more consistent gastric emptying, a lower chance of dose dumping, and flexible drug release patterns [1]. Among the available production methods, extrusion-spheronization is preferred because it can handle high amounts of active ingredients without creating large particles, and it also allows for the easy combination of multiple drugs in one unit at any ratio [2]. The aim of this research is to determine the optimal parameters of the extruder, namely, the screw rotation speed, liquid addition rate and powder feeding rate, to determine the independent process parameters of the spheroniser, and to measure the loss-on-drying values, particle size distribution, and morphology of extrudates. The required machines to produce pellets are a twin-screw extruder, a spheroniser, a peristaltic pump, and a cooling system. Extrudates were obtained by using a mixture of microcrystalline cellulose, corn starch, lactose monohydrate and 10% povidone solution.
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Personalized 3D-Printed Gastroretentive Drug Forms with Metronidazole
Views:213D printing is increasingly recognized as a versatile manufacturing approach, enabling the production of devices that are difficult or costly to fabricate using conventional methods. In this study, we aimed to develop a hollow, 3D-printed capsule designed for incorporation of a molten matrix containing an active pharmaceutical ingredient, and to evaluate its potential for gastric retention through controlled drug release. Capsule shells were fabricated from polylactic acid using fused deposition modeling and subsequently filled with polyethylene glycol-based melts. Micro-CT was employed to assess internal structure and integrity. Drug release profiles were measured for different matrix compositions, and texture as well as compositional analyses were performed on both filled and unfilled capsules. Our findings demonstrate that the 3D-printed PLA shells provide sufficient mechanical strength and, depending on the matrix composition, enable controlled, zero-order drug release for up to five hours. These results highlight the potential of 3D-printed capsules as a customizable, gastro-retentive drug delivery system, offering opportunities for personalized therapies.
