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Effect of allithiamine on the level of hyperglycaemia-induced advanced glycation end products
41-44Views:583Diabetes mellitus is a rapidly growing public health burden in both developed and developing countries. Diabetes mellitus is accompanied by hyperglycaemia, which can cause tissue injury by several mechanisms. One of these is the formation of advanced glycation end-products (AGEs). In this study, the effect of allithaimine, a fat-soluble thiamine derivative, was investigated on hyperglycaemia-induced AGEs levels using human umbilical cord vein endothelial cells (HUVECs) as a hyperglycaemic model. HUVECs were isolated by enzymatic digestion, characterized by flow cytometer and treated 30 mM glucose plus allithaimine or thiamine or cell maintenance medium as control. Allithiamine was synthesized and purified. The structure of the synthesized and isolated compound was verified by reverse phase HPLC and MALDI-TOF. AGEs were evaluated by ELISA. Collectively, our results indicate that allithiamine can reduce level of the hyperglycaemia-induced AGEs similar to thiamine.
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Examination of the angle position on the cone dispenser
204-207Views:243The most important distributing construction of small plot seed-drills and fertiliser dispensers is the cone dispenser. The cone dispenser can operate based on simple gravity or with an Oyjord-type cone-cell or Hege-type cone-belt structure. The unevenness of spreading of each type is significantly influenced by the aberration of the vertical angle position of the cone dispenser. An approximate method was improved modelling of the fault of the cone dispenser. In my article, I will provide information about the essence of the model and its derivations.
On the model, I cover the cone piston with a theoretical net and at random scale between each scale interval I count the forces acting on the grain and the movement of the grain. If I set the scale of the net close enough, with good proximity, I get the whole orbit. The unevenness of dispensing can be calculated from the position of the grains getting to the bottom of the cone in case of different geometric data. My measurements imply that an approximate method is able to model both the tendency and the value of the deviation caused by the fault of the angle position. Both the theoretical model and the measurement prove that 2-3° deviation results in significant change in the unevenness of dispensing. -
Evaluation of the current situation of the Hungarian higher education based on a few indexes
121-125Views:199Around the Millennium we experienced the worldwide development and the growing importance of the role of higher education played in the social and economic development. A few years later, however, a crisis appeared in the situation of higher education (Kadocsa, 2002). The Hungarian higher education system faces the perspective of serious changes in its fundamental principals – such as its main activities and the economical ways which are used to finance these activities – even if only parts of the new educational scheme come into effect. Considering this fundamental activity aspect of the issue, there are new challenges which make necessary to rethink the role and aim of higher education and to define the new tasks needed in connection with education, research and other services. Hungarian Education needs to be renewed and improved to avoid a complete
break away; therefore, future priorities and tasks in order to fulfill these priorities need to be defined (Vincze and Harsányi, 2011). The new conception seems to be based on restrictions of the budget as it is experienced recently: a new structure available for a smaller part of society with a restricted budget has been under development. However, not even a battle, let alone a war can be won without money, horses and arms. The recent financial restrictions as well as the parts of the Széll Kálmán plan concerning education prove that serious amounts of governmental funds is taken away from education. The international improvement tendencies contradict to basically all of these Hungarian priorities.
All in all, no reform or change – no matter how much wanted – can be achieved without appropriate funds. -
New wonder of an old hormone: Hungarian sour cherry varieties as natural melatonin sources
65-72Views:456Agriculture has always been an important role in economy, food supplies, sustainability of society During our experimental work an effective extraction procedure has been developed for melatonin. Further chromatography was developed the quantitative and qualitative determination of melatonin. A compound that was equal to the standard was purified from the extract by preparative HPLC technique and the structure of the purified sample was confirmed by MALDI-TOF-MS and NMR analysis. Based on our measurements, harvested in the state of biological maturity Hungarian sour cherry cultivars contain high levels of melatonin.
Our results show that "VN4" variety has extremely high melatonin content, 9.893 ug g-1 and suggest that "VN4" which were selected from the "Bosnyák" varieties is melatonin accumulating. The average value of the melatonin content of Hungarian sour cherry cultivars is 2.319 ug g-1.