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Formulation of Novel Liquid Crystal (LC) Formulations with Skin-Permeation-Enhancing Abilities of Plantago lanceolata (PL) Extract and Their Assessment on HaCaT Cells
Views:119Exposure to reactive oxygen species can easily result in serious diseases, such as hyperproliferative skin disorders or skin cancer. Herbal extracts are widely used as antioxidant sources in different compositions. The importance of antioxidant therapy in inflammatory conditions has increased. Innovative formulations can be used to improve the effects of these phytopharmacons. The bioactive compounds of Plantago lanceolata (PL) possess different effects, such as anti-inflammatory, antioxidant, and bactericidal pharmacological effects. The objective of this study was to formulate novel liquid crystal (LC) compositions to protect Plantago lanceolata extract from hydrolysis and to improve its effect. Since safety is an important aspect of pharmaceutical formulations, the biological properties of applied excipients and blends were evaluated using assorted in vitro methods on HaCaT cells. According to the antecedent toxicity screening evaluation, three surfactants were selected (Gelucire 44/14, Labrasol, and Lauroglycol 90) for the formulation. The dissolution rate of PL from the PL-LC systems was evaluated using a Franz diffusion chamber apparatus. The antioxidant properties of the PL-LC systems were evaluated with 2,2-diphenyl-1-picrylhydrazyl (DPPH) and malondialdehyde (MDA) assessments. Our results suggest that these compositions use a nontraditional, rapid-permeation pathway for the delivery of drugs, as the applied penetration enhancers reversibly alter the barrier properties of the outer stratum corneum. These excipients can be safe and highly tolerable thus, they could improve the patient’s experience and promote adherence.
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Formulation and testing of prebiotic capsules
Views:175Prebiotics are non-digestible food ingredients that reach the colon unchanged, serving as nutrients for bacterial strains that are beneficial to the body and helping them to multiply. The aim of the present experimental work was to formulate a capsule with a prebiotic composition. The capsule composition was formulated from different prebiotics: inulin, galacto-oligosaccharide, pectin. In addition to prebiotics, the product contains zinc citrate. The pharmacopoeia and other dosage form test of the powder mixture and capsules were examined. The average weight of the capsules, the uncompressed and compressed density of the capsule filling, the particle size distribution by sieve analysis and the fluidity of the powder mixture were determined. In addition, the homogeneous distribution of zinc citrate in the powder mixture was investigated using an analytical method. The results of the tests confirmed that the composition is technologically appropriate. The chosen manufacturing technology and sequence of operations ensure a homogeneous distribution of components and the reproducibility.