With the coming of the Ptolemaic dynasty to the Egyptian throne, the goddess Isis goes through a series of changes that will turn her into a very different divinity. This new Hellenistic or Greco-Roman Isis not only stands out for the degree of expansion attained throughout the Mediterranean world but also for displaying a series of attributes, among which we highlight one in particular: Her role as goddess of the Sea. This not only changed the attitude of her devotees but also entailed deeper ritual implications, festivities and iconographic motifs. There are innumerable variations that brought about her “metamorphosis” into a maritime deity, especially since this was one of the most popular facets of Isis that penetrated the Roman Empire.