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Assessing animal species at risk for SARS-CoV-2 transmission: Bioinformatic analysis based on Angiotensin-Converting-Enzyme (ACE2) homology in edible and other animals
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The study aimed to identify animals, particularly edible animals, that may be susceptible to infection by SARS-CoV-2. This was achieved through bioinformatics techniques, including alignment analysis of genomic sequences from selected animals, identity percentages comparison, and phylogenetic analysis based on the interaction between ACE2 and the receptor-binding domain (RBD) of SARS-CoV-2. This analysis identified rabbits, donkeys, alpacas, horses, wild boars, field rats, and monkeys as potentially susceptible edible animals. Additionally, primates were highlighted due to their close genetic resemblance to humans. Overall, 22 animals worldwide were identified as susceptible, marking them as possible reservoirs and hosts for the virus, emphasizing the need for vigilance around animals that humans may contact or consume.