The year 2021 marked the 100th anniversary of the inception of the Department of Medical Chemistry at the University of Debrecen. The Department’s history goes back to December 15th, 1921, when the Dean of the Medical Faculty Frigyes Verzár proposed to the Faculty Council the establishment of a „Chemistry Department”. Although the Council only approved this proposal in 1922, the Department was established retroactively with a foundation date of 1921. The Department was led by a few short-term and four long-term professors (János Bodnár, János Straub, György Bot and Pál Gergely) and each of them left their marks on the department. They should be credited for the constant development of a department that - besides teaching basic chemistry, introductory biochemistry and molecular biology to generations of medical students – has also pioneered biochemistry-oriented research deeply rooted in medicine.